Calorie restriction (CR) is the most potent, non-pharmacological intervention to support
metabolic health. The effects of calorie restriction exceed weight loss. Consistent throughout
many studies, calorie restriction induces a reduction in energy expenditure that is larger than
the loss of metabolic mass, ie fat-free mass and fat mass, can explain. Per prevailing
theories of mammalian aging, this disproportionate reduction in metabolic rate, defined as
metabolic adaptation, reduces oxidative damage and thereby delays age-associated …