[HTML][HTML] Longitudinal profile of circulating T follicular helper lymphocytes parallels anti-HLA sensitization in renal transplant recipients
FL Cano-Romero, RL Goya, A Utrero-Rico… - American Journal of …, 2019 - Elsevier
Antibody-mediated rejection is responsible for 30%-50% of renal graft failures.
Differentiation of B cells into antibody-producing plasmablasts depends on the collaboration
of follicular helper T cells (Tfh). We analyzed circulating Tfh (cTfh) in kidney recipients and
studied cTfh relationship with anti-HLA antibody production and graft outcome. cTfh were
longitudinally analyzed in a prospective cohort of patients (n= 206), pre-and
posttransplantation. Clinical data, HLA sensitization, and cTfh function were recorded. Both …
Differentiation of B cells into antibody-producing plasmablasts depends on the collaboration
of follicular helper T cells (Tfh). We analyzed circulating Tfh (cTfh) in kidney recipients and
studied cTfh relationship with anti-HLA antibody production and graft outcome. cTfh were
longitudinally analyzed in a prospective cohort of patients (n= 206), pre-and
posttransplantation. Clinical data, HLA sensitization, and cTfh function were recorded. Both …
