Purpose We aimed to clarify the role of particulate allergen exposure to the conjunctiva in
the development of allergic conjunctivitis. Methods We administered ragweed pollen
suspension, pollen extract, pollen shell, particulate air pollutants, and their combinations to
the mouse conjunctiva five days a week without prior sensitization. Clinical signs were
scored. Histological changes, cellular infiltrations, mRNA expressions, lymph node cell
recall responses, and serum immunoglobulin levels were assessed. Immune cell-depleting …