Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal
B Lou, W Wu, L Zeng, W Zhou, X Zhang, X Zhou, Z Liu… - The Ocular Surface, 2022 - Elsevier
Purpose Ocular allergy leads to acute and chronic inflammation that may deteriorate the
conjunctiva and other ocular tissue. The conjunctiva is covered with abundant lymphatic
vessels but how the conjunctival lymphatic system patriciates in the development of allergic
eye disease (AED) remains to be elucidated. Methods and results By using ovalbumin
(OVA)+ pertussis toxin (PTX) as a sensitizer followed by daily OVA challenges, we induced
optimized AED manifestations in mice. We show that conjunctival lymphatics underwent …
conjunctiva and other ocular tissue. The conjunctiva is covered with abundant lymphatic
vessels but how the conjunctival lymphatic system patriciates in the development of allergic
eye disease (AED) remains to be elucidated. Methods and results By using ovalbumin
(OVA)+ pertussis toxin (PTX) as a sensitizer followed by daily OVA challenges, we induced
optimized AED manifestations in mice. We show that conjunctival lymphatics underwent …
