Inflammation-induced lymphangiogenesis and lymphatic dysfunction

S Liao, PY von der Weid - Angiogenesis, 2014 - Springer
S Liao, PY von der Weid
Angiogenesis, 2014Springer
The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell
trafficking. These functions are paramount in the establishment and development of an
inflammatory response. In the past decade, an increasing number of reports has revealed
that marked changes, such as lymphangiogenesis and lymphatic contractile dysfunction
occur in both vascular and nodal parts of the lymphatic system during inflammation, as well
as other disease processes. This review provides a critical update on the role of the …
Abstract
The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflammatory response. In the past decade, an increasing number of reports has revealed that marked changes, such as lymphangiogenesis and lymphatic contractile dysfunction occur in both vascular and nodal parts of the lymphatic system during inflammation, as well as other disease processes. This review provides a critical update on the role of the lymphatic system in disease process such as chronic inflammation and cancer and examines the changes in lymphatic functions the diseases cause and the influence these changes have on the progression of the diseases.
Springer