[HTML][HTML] Glycomics using mass spectrometry
M Wuhrer - Glycoconjugate journal, 2013 - Springer
Glycoconjugate journal, 2013•Springer
Mass spectrometry plays an increasingly important role in structural glycomics. This review
provides an overview on currently used mass spectrometric approaches such as the
characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of
proteins and the analysis of glycosphingolipids. The given examples are demonstrating the
application of mass spectrometry to study glycosylation changes associated with congenital
disorders of glycosylation, lysosomal storage diseases, autoimmune diseases and cancer.
provides an overview on currently used mass spectrometric approaches such as the
characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of
proteins and the analysis of glycosphingolipids. The given examples are demonstrating the
application of mass spectrometry to study glycosylation changes associated with congenital
disorders of glycosylation, lysosomal storage diseases, autoimmune diseases and cancer.
Abstract
Mass spectrometry plays an increasingly important role in structural glycomics. This review provides an overview on currently used mass spectrometric approaches such as the characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of proteins and the analysis of glycosphingolipids. The given examples are demonstrating the application of mass spectrometry to study glycosylation changes associated with congenital disorders of glycosylation, lysosomal storage diseases, autoimmune diseases and cancer.
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