[HTML][HTML] Simultaneous inhibition of FXR and TGR5 exacerbates atherosclerotic formation
S Miyazaki-Anzai, M Masuda, S Kohno, M Levi… - Journal of lipid …, 2018 - ASBMB
Simultaneous activation of bile acid receptors farnesoid X receptor (FXR) and G protein-
coupled bile acid receptor 1 (TGR5) by INT-767 significantly reduces atherosclerotic
formation. In this study, we investigated the effect of simultaneous inactivation of these bile
acid receptors in atherosclerosis and which bile acid receptor mediates the anti-atherogenic
effect of INT-767. To investigate the role of simultaneous inactivation of FXR and TGR5 in
vivo, we generated LDL receptor knockout (LDLR) KO mice with FXR and TGR5 dual …
coupled bile acid receptor 1 (TGR5) by INT-767 significantly reduces atherosclerotic
formation. In this study, we investigated the effect of simultaneous inactivation of these bile
acid receptors in atherosclerosis and which bile acid receptor mediates the anti-atherogenic
effect of INT-767. To investigate the role of simultaneous inactivation of FXR and TGR5 in
vivo, we generated LDL receptor knockout (LDLR) KO mice with FXR and TGR5 dual …
